Expounding upon the nature of "human dignity", both theoretically and practically, establishes the supremacy of one school of thought over its rivals. Scholars have extensively explored the concept of human dignity within the framework of Islamic philosophy and the Quranic discourse. This research aims to identify the foundations, components, and indices of the principle of human dignity from the perspective of Ayatollah Seyed Ali Khamenei. Employing a descriptive-analytical and comparative method, it seeks to compare his statements with the foundations and components of human dignity from the perspective of humanists by analyzing the Leader’s statements and inferential approach. The findings of this research show that the basis of the principle of human dignity in the thoughts of His Eminence is based on an Islamic-centered human, which itself has three components: "divine creation," "divine caliphate," and "preservation of human dignity and values." These three components have several characteristics that together constitute the principle of human dignity in Ayatollah Khamenei’s thought. This view is contrary to the humanist view of human dignity, as from their perspective, human creation is natural and non-divine; moreover, they have said that humans themselves are the only source of values, whereas, in Ayatollah Khamenei's intellectual outlook, which is derived from Islam, monotheism is the core in explaining human values, and rationalism in the humanist school, as the only tool for human self-sufficiency, is in contradiction with Ayatollah Khamenei's definition of reason and its theoretical and practical status.